The　Ga0.25Zn4.67S5.08　catalysts　were　prepared　by　ultrasonic　spray　pyrolysis　with　thiourea　as　a　precursor.　The　crystal　structure,　optical　properties,　specific　surface　area,　chemical　composition,　surface　morphology,　and　internal　structure　of　the　prepared　samples　were　characterized　by　XRD,　UV-Vis　DRS,　BET,　XPS,　SEM,　and　TEM,　respectively.　The　disinfection　performance　and　the　main　active　species　of　the　synthesized　catalysts　under　visible　light　irradiation　were　investigated　with　E.　coli　K12.　The　study　results　indicate　that　Ga0.25Zn4.67S5.08　prepared　at　400　degrees　C　exhibited　the　best　antibacterial　performance　with　complete　kill　of　E.　coli　K12　within　4h.　The　antibacterial　performance　of　the　prepared　sample　is　also　higher　than　that　prepared　by　the　hydrothermal　method.　The　result　of　the　radical　trapping　experiment　indicates　that　the　photogenerated　holes　play　a　dominant　role　in　the　disinfection　process.