Multidrug　combination　therapy　based　on　drug　delivery　systems　(DDSs)　has　great　potential　for　cancer　treatment.　Stimuli-sensitive　DDSs　further　enhance　therapeutic　efficacy　by　providing　controllable　drug　delivery.　Herein,　the　phospholipid　compound　DPPC　(1,2-dipalmitoyl-sn-glycero-3-phosphocholine)　was　used　to　construct　thermosensitive　liposomes　to　load　the　photosensitizer　ZnPc(PEG)(4)(zinc　phthalocyanine　substituted　by　tetraethylene　glycol)　for　molecular　imaging,　and　photodynamic　and　photothermal　therapy,　together　with　doxorubicin　(DOX)　for　chemotherapy.　Interestingly,　ZnPc(PEG)(4)as　an　amphipathic　molecule　was　found　to　be　important　in　the　construction　of　the　liposomes,　and　it　provided　liposomes　with　improved　stability.　The　thus-obtained　liposomes　ZnPc(PEG)(4):DOX@LiPOs　were　demonstrated　to　have　enhanced　ROS　production　capacity,　heat　generation　properties　and　a　photo-triggered　doxorubicin　release　effect,　and,　in　cellular　experiments,　increased　cytotoxicity　and　apoptotic　cell　proportions,　compared　to　ZnPc(PEG)(4)@LiPOs　and　DOX@LiPOs.　ZnPc(PEG)(4)loaded　in　lipid　bilayers　showed　stronger　intracellular　ROS　production　ability　compared　to　free　ZnPc(PEG)(4).In　vivostudies　indicated　that　ZnPc(PEG)(4):DOX@LiPOs　exhibited　enhanced　tumor　accumulation,　increased　anti-cancer　effects　and　reduced　liver　retention.　These　photo-triggered　liposomes　constructed　by　the　photosensitizer　ZnPc(PEG)(4)can　also　be　used　to　package　other　cargo　for　combined　target　tumor　therapy　and　molecular　imaging.