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Proteomic profiling points to the significance of adipocyte-derived extracellular vesicles in diet-induced obesity
Extracellular vesicles (EVs) are lipid-bilayer membrane-enclosed vesicles well known to mediate cell-cell communication to maintain normal physiological...
文献获取Neutrophils undergo switch of apoptosis to NETosis during murine fatty liver injury via S1P receptor 2 signaling
Inappropriate neutrophil infiltration and subsequent neutrophil extracellular trap (NET) formation have been confirmed to be involved in chronic inflamm...
miR-146a is a pivotal regulator of neutrophil extracellular trap formation promoting thrombosis
Neutrophil extracellular traps (NETs) induce a procoagulant response linking inflammation and thrombosis. Low levels of miR-146a, a brake of inflammatory response, are involved in higher risk for cardiovascular events, but the mechani...
Regulatory T cell and neutrophil extracellular trap interaction contributes to carcinogenesis in non-alcoholic steatohepatitis
However, how NETs interact with Tregs in the development of NASH-associated hepatocellular carcinoma (NASH-HCC) is not known.#A choline-deficient, high-...
Inhibition of NET Release Fails to Reduce Adipose Tissue Inflammation in Mice
Obesity-associated diseases such as Type 2 diabetes, liver disease and cardiovascular diseases are profoundly mediated by low-grade chronic inflammation...
Impact of chronic hyperglycaemia on the coronary microcirculation – benefits of targeting IL-36 and diet reversal
Following myocardial infarction (MI), patients with type 2 diabetes mellitus (T2DM) have poorer prognosis which may be linked to increased susceptibilit...
Low shear stress exacerbates atherosclerosis by inducing the generation of neutrophil extracellular traps via Piezo1-mediated mechan...
Low shear stress (LSS) promotes the formation of neutrophil extracellular traps (NETs).Neutrophils sense LSS through Piezo1.LSS promotes NETosis through...
Effect of adipokine priming upon neutrophil oxygen radical and extracellular trap release in response to stimulation by periodontal ...
Project 1:\\udObesity is a major public health problem worldwide of increasing prevalence. It is characterised by a low grade chronic inflammatory state, which contributes to obesity-associated morbidity. A body of evidence suggests t...
Influence of glucocorticoids on time-of-day-dependent variations in IgE-, histamine-, and platelet-activating factor-mediated system...
A time-of-day-dependent variation in IgE-mediated passive systemic anaphylaxis was previously reported in ICR mice. In the present study, we investigate...
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Scrutinizing Mechanisms of the 'Obesity Paradox in Sepsis': Obesity Is Accompanied by Diminished Formation of Neutrophil Extracellul...
Systemic inflammation is a detrimental condition associated with high mortality. However, obese individuals seem to have higher chances of surviving sep...
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