Engineering　of　microbial　cells　to　produce　high　value　chemicals　is　rapidly　advancing.　Yeast,　bacteria　and　microalgae　are　being　used　to　produce　high　value　chemicals　by　utilizing　widely　available　carbon　sources.　However,　current　extraction　processes　of　many　high　value　products　from　these　cells　are　time-and　labor-consuming　and　require　toxic　chemicals.　This　makes　the　extraction　processes　detrimental　to　the　environment　and　not　economically　feasible.　Hence,　there　is　a　demand　for　the　development　of　simple,　effective,　and　environmentally　friendly　method　for　the　extraction　of　high　value　chemicals　from　these　cell　factories.　Herein,　we　hypothesized　that　atomically　thin　edges　of　graphene　having　ability　to　interact　with　hydrophobic　materials,　could　be　used　to　extract　high　value　lipids　from　cell　factories.　To　achieve　this,　array　of　axially　oriented　graphene　was　deposited　on　iron　nanoparticles.　These　coated　nanoparticles　were　used　to　facilitate　the　release　of　intracellular　lipids　from　Yarrowia　lipolytica　cells.　Our　treatment　process　can　be　integrated　with　the　growth　procedure　and　achieved　the　release　of　50%　of　total　cellular　lipids　from　Y.　lipolytica　cells.　Based　on　this　result,　we　propose　that　nanoparticles　coated　with　axially　oriented　graphene　could　pave　efficient,　environmentally　friendly,　and　costeffective　way　to　release　intracellular　lipids　from　yeast　cell　factories.