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[期刊论文]

The smooth muscle pharmacology of maximakinin, a receptor-selective, bradykinin-related nonadecapeptide from the venom of the Chinese toad, Bombina maxima

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author:

O'Rourke, M. (O'Rourke, M..) [1] | Chen, T. (Chen, T..) [2] | Hirst, D.G. (Hirst, D.G..) [3] | Unfold

Indexed by:

Scopus

Abstract:

Structural homologues of vertebrate regulatory peptides found in defensive skin secretions of anuran amphibians often display enhanced bioactivity and receptor binding when compared with endogenous mammalian peptide ligands. Maximakinin, a novel N-terminally extended bradykinin (DLPKINRKGPRPPGFSPFR) from the skin venom of a Chinese toad (Bombina maxima), displays such activity enhancement when compared with bradykinin but is additionally highly selective for mammalian arterial smooth muscle bradykinin receptors displaying a 50-fold increase in molar potency in this smooth muscle type. In contrast, a 100-fold decrease in molar potency was observed at bradykinin receptors in intestinal and uterine smooth muscle preparations. Maximakinin has thus evolved as a "smart" defensive weapon in the toad with receptor/tissue selective targeting. Natural selection of amphibian skin venom peptides for antipredator defence, through inter-species delivery by an exogenous secretory mode, produces subtle structural stabilisation modifications that can potentially provide new insights for the design of selectively targeted peptide therapeutics. © 2004 Elsevier B.V. All rights reserved.

Keyword:

Amphibian; Bradykinin; Peptides; Receptor

Community:

  • [ 1 ] [O'Rourke, M.]School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, United Kingdom
  • [ 2 ] [Chen, T.]School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, United Kingdom
  • [ 3 ] [Chen, T.]Institute of Biotechnology, Fuzhou University, Fuzhou 350002, Fujian Province, China
  • [ 4 ] [Hirst, D.G.]School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, United Kingdom
  • [ 5 ] [Rao, P.]Institute of Biotechnology, Fuzhou University, Fuzhou 350002, Fujian Province, China
  • [ 6 ] [Shaw, C.]School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, United Kingdom

Reprint 's Address:

  • [Shaw, C.]School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, United Kingdom

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Source :

Regulatory Peptides

ISSN: 0167-0115

Year: 2004

Issue: 1-3

Volume: 121

Page: 65-72

2 . 5 3 1

JCR@2004

1 . 8 1 3

JCR@2015

JCR Journal Grade:2

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count: 20

30 Days PV: 2

Affiliated Colleges:

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管理员  2024-08-22 19:23:49  更新被引

管理员  2020-11-19 19:27:11  创建

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